Endocrine Abstracts

The aim: To evaluate effectiveness of complex therapy in patients with comorbidity of type 2 diabetes (DM2) and essential hypertension (EH) depending on genetic polymorphism peroxisome proliferator-activating receptor-γ2 (PPARγ2). Before and after 3 months of treatment we examined 145 patients with EH stage II, grade and DM2 moderate, subcompensated aged 45–60 years: group 1 (71 patients) received standart therapy (telmisartan, indapamide, metformin, gliclazide,...

Objective: To establish possible associations of the polymorphism of the insulin receptor substrate−1 (IRS-1) gene with the severity of various components of metabolic syndrome in patients with arterial hypertension (AH). We examined 187 patients with AH aged 45–55 years (with history of hypertension less than 5 years, unsystematic administration of antihypertensive drugs and/or failure to achieve target blood pressure (BP) levels when prescribing drug therapy). The...

Background: The aim was to establish the features of metabolic disorders and the state of the renin–angiotensin–aldosterone system (RAAS) in obese patients with true and pseudo–resistant arterial hypertension (AH).Material and Methods: The study included 200 patients with uncontrolled AH and obesity. Patients were initially prescribed dual antihypertensive therapy. Those patients who did not reach target blood pressure (BP) levels after...

Objective: to conduct a comparative assessment between metabolic and hemodynamic parameters in obese patients with true and pseudo-resistant (due to different causes) hypertension.Materials and methods: The study included 302 patients with uncontrolled hypertension and obesity. Initial treatment efficacy was assessed 3 months after dual therapy was administered. Those patients who did not reach target blood pressure (BP) in dual therapy were transferred ...

The aim: To establish unfavorable genetic polymorphisms on the development of comorbidity of DM2 and EH in Ukrainian population and to evaluate the effectiveness of α-lipoic acid appointment (α-LC) in complex therapy in patients with 3-4 crossed unfavorable genetic polymorphisms.The primary examination of 167 patients with DM2 in combination with EH showed that A/C and C/C genotypes of AGTR1, Pro/Pro genotype of PPARγ2, Arg/Arg ...

The presence of type 1 diabetes (DM1) affects the heart rate variability (HRV). However, there are conflicting data on the impact of hyper- and hypoglycaemia on the parameters of cardiovascular autonomic regulation.The aim: To investigate the possible association of glucose fluctuation with HRV in longstanding DM1.Design and methods: We examined 49 patients with longstanding (>20 years) history of DM1 (without overt cardiovascu...